University of Chicago :: Department of Pathology ::

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Sandeep Gurbuxani MD, PhD

Instructor

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Department of Pathology
University of Chicago
5841 S. Maryland Avenue

MC 1089, AMB P-309
Chicago, IL 60637-1470
Phone: 773.702.7279
Fax: 773.702.1200
sandeep.gurbuxani@uchospitals.edu

Clinical Interests

Hematopathology

Research Interests

I am interested in mechanisms of resistance to chemotherapy induce cell death in cancer. The focus of my current research is the mechanism of glucocorticoid induced cell death (and the resistance to this cell death) in acute lymphoblastic leukemia (ALL).

While significant progress has been made in the therapy of childhood ALL, the outcome for adult ALL and relapsed ALL remains poor.
Glucocorticoids (GCs) such as dexamethasone and prednisone are the mainstay of ALL therapy. Multiple studies in childhood ALL have demonstrated GC resistance measured in vitro as well as in vivo after GC monotherapy to be the single most important predictor of response to therapy in childhood ALL. In spite of the crucial role of GCs in ALL therapy, the mechanisms of cell death induced upon GC exposure are poorly understood. Understanding the pathway(s) involved in GC mediated cell death is a crucial first step in understanding the mechanisms of GC resistance in ALL.

I am also interested in the process of hematopoiesis - specifically the pro survival signals required during hematopoietic differentiation.
Additional interests include the biology of myeloproliferative neoplasms.

Hematopathology

Publications

Gurbuxani S, Anastasi J. What to Do When You Suspect Gastrointestinal Lymphoma: A Pathologist's
Perspective. Clin Gastroenterol Hepatol. 2007 Mar 1; [Epub ahead of print]
Gurbuxani S. CD36 - a marker for drug sensitive acute megakaryoblastic leukemia. Leuk Lymphoma. 2006 Oct;47(10):2004-5.
Gurbuxani S, Xu Y, Keerthivasan G, Wickrema A, Crispino JD. Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11480-5.
Schmitt E, Parcellier A, Ghiringhelli F, Casares N, Gurbuxani S, Droin N, Hamai A, Pequignot M, Hammann A, Moutet M, Fromentin A, Kroemer G, Solary E, Garrido C. Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C. Cancer Res. 2004 Apr 15;64(8):2705-11.
Schmitt E, Parcellier A, Gurbuxani S, Cande C, Hammann A, Morales MC, Hunt CR, Dix DJ, Kroemer RT, Giordanetto F, Jaattela M, Penninger JM, Pance A, Kroemer G, Garrido C. Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 2003 Dec 1;63(23):8233-40.

Publications (continued)

Greene ME, Mundschau G, Wechsler J, McDevitt M, Gamis A, Karp J, Gurbuxani S, Arceci R, Crispino JD. Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. Blood Cells Mol Dis. 2003 Nov-Dec;31(3):351-6.
Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene. 2003 Oct 2;22(43):6669-78.
Gurbuxani S, Vyas P, Crispino JD. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome.
Blood. 2004 Jan 15;103(2):399-406.
Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 2003 Jun 1;101(11):4298-300.
Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H. DNA binding is required for the apoptogenic action of apoptosis inducing factor.
Nat Struct Biol. 2002 Sep;9(9):680-4.
Gurbuxani S, Bruey JM, Fromentin A, Larmonier N, Parcellier A, Jaattela M, Martin F, Solary E, Garrido C. Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Oncogene. 2001 Nov 8;20(51):7478-85.
Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jaattela M, Penninger JM, Garrido C, Kroemer G. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 2001 Sep;3(9):839-43.
Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo AP, Kroemer G, Solary E, Garrido C. Hsp27 negatively regulates cell death by interacting with cytochrome c.
Nat Cell Biol. 2000 Sep;2(9):645-52.

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