Loren Joseph, MD
Contact
University of Chicago Hospital, MC00045841 S. Maryland Avenue
Chicago, IL 60637-1470
Phone: (773) 702-5338
Fax: (773) 702-6268
ljlj@midway.uchicago.edu
Clinical Interests
Molecular Diagnostics/Javascript authoring for clinical chemistry education.Research Interest
Microarray identification of differentially regulated genes (or any gene that looks cool and is not known to be expressed in colon) in an experimental rat model of colon cancer. The most interesting candidates at present are a gene normally thought of as only occurring in peripheral nerve and implicated in growth arrest, and a gene involved in dampening the inflammatory response.Selected Publications
- Michaelis, LC; Joseph, L; Lin, SP; Kline, J; Artz, A; Pollyea, D; Van Besien, K. Relationship of Day 30 and Day 100 Chimerism to Survival, GVHD and Relapse after Reduced-Intensity Allogeneic Transplantation for Hematologic Malignancies Meeting (accepted 2006).
- Greg Cohen, Reba Mustafi, Anusara Chumsangsri, Nathaniel Little, Jeff Nathanson, Sonia Cerda, Sujatha Jagadeeswaran, Urszula Dougherty, Loren Joseph, John Hart, Lisa Yerian, Maria Tretiakova, Weihua Yuan, Piotr Obara, Sharad Khare, Frank A. Sinicrope, Alessandro Fichera, Gerry R. Boss, Robert Carroll and Marc Bissonnette. "Epidermal Growth Factor Receptor Signaling is Up-regulated in Human Colonic Aberrant Crypt Foci". Cancer Research (accepted 2006).
Selected Publications (continued)
- Timothy P. Kinney, Nina Merel, John Hart, Loren Joseph and Irving Waxman. "Microsatellite Analysis of Sporadic Flat and Depressed Lesions of the Colon". Digestive Diseases and Sciences 50:327 - 330 (2005).
- KT Patton, HM chen, L Joseph, XJ Yang. "Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia". Histopathology. 47(6):597-601 (2005). Loren Joseph. "RNA reference materials for gene expression studies. RNA metrology: forecast calls for partial clearing". Clinical Chemistry. 50(8):1290-2, 2004.
- Sharad Khare, Reba Mustafi, Sonia Cerda, Weihua Yuan, Maria Tretiakovaý, Allen Samarel§, Greg Cohen, Julia L. Wang, Christopher Moore, Ramesh Wali, Cory Holgren, Loren Joseph, Alessandro Fichera, Yan Chun Li and Marc Bissonnette. (2006). "Opposing Effects of Tumor-promoting and Tumor-inhibiting Bile Acids on Ras Signaling and Cox-2 Induction in AOM Premalignancy and in Colon Cancer Cells". Carcinogenesis (submitted 2006).
- Members of the Subcommittee Molecular Methods for Microarrays "MM12-P, Diagnostic Nucleic Acid Microarrays; Proposed Guideline" (2006).
- Members of the Subcommittee for Protocols to Validate Laboratory Information Systems (Area Committee on Automation and Informatics). " AUTO8-P, Protocols to Validate Laboratory Information Systems; Proposed Guideline" (submitted 2006)
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