University of Chicago :: Department of Pathology ::

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John Anastasi, MD

Associate Professor
Assistant Director, Hematopathology
Medical Director, Flow Cytometry
Residency Program Director

Contact

Department of Pathology
University of Chicago
5841 S. Maryland Avenue
Chicago, IL 60637-1470
Phone: 773.702.6196
Fax: 773.702.1200
john.anastasi@uchospitals.edu

Clinical Interest

Dr. Anastasi is the Assistant Director of Hematopathology, and the Medical Director of the Clinical Flow Cytometry area located in the Clinical Hematology laboratory. He rotates on the hemato-pathology sign-out service, interpreting bone marrow biopsies/aspirates, lymph node biopsies, and other hemepath-related material, and on the Clinical Hematology Lab service dealing with body fluid/CSF analysis, clinical flow cytometry and hematology lab issues. He also helps Dr. Vardiman with the evaluation of acute leukemia cases from the cooperative Cancer and Leukemia Group B (CALGB) acute leukemia program.

Research Interests

Dr. Anastasi's research interests initially revolved around Fluorescent in situ Hybridization (FISH) analysis which he was the first to develop for the evaluation of clinical specimens at U of C. He has been utilizing the technique for diagnostic and research applications including initial diagnostic and classification evaluations of specimens from patients with leukemia, and evaluations for residual disease/effect of therapy. He adapted the technique for correlative studies of morphology and genetics and has been using this for cell lineage studies in leukemia. His recent research interests include the evaluation of a new type of Acute Myeloid leukemia which resembles APL, and he continues to study issues in lineage restriction in normal hematopoiesis and leukemic disorders.

Selected Publications

Djokic M, Le Beau MM, Swinnen LJ, Smith SM, Rubin CM, Anastasi J, Carlson KM. Post-transplant lymphoproliferative disorder subtypes correlate with different recurring chromosomal abnormalities. Genes Chromosomes Cancer. 2006 Mar;45(3):313-8.
Buonamici S, Li D, Mikhail FM, Sassano A, Platanias LC, Colamonici O, Anastasi J, Nucifora G. EVI1 abrogates interferon-alpha response by selectively blocking PML induction. J Biol Chem. 2005 Jan 7;280(1):428-36. Epub 2004 Nov 1.
Baron BW, Anastasi J, Montag A, Huo D, Baron RM, Karrison T, Thirman MJ, Subudhi SK, Chin RK, Felsher DW, Fu YX, McKeithan TW, Baron JM. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14198-203. Epub 2004 Sep 16.
Blum W, Mrozek K, Ruppert AS, Carroll AJ, Rao KW, Pettenati MJ, Anastasi J, Larson RA, Bloomfield CD. Adult de novo acute myeloid leukemia with t(6;11)(q27;q23): results from Cancer and Leukemia Group B Study 8461 and review of the literature. Cancer. 2004 Sep 15;101(6):1420-7.

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